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Efavirenz may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.

Some side effects of efavirenz can be serious. Serious side effects of efavirenz include serious mental health problems, liver problems, and severe rash. (See section above: What are the most important things to know about efavirenz?)

Other possible side effects of efavirenz include:

Nervous system symptoms, including dizziness, drowsiness, trouble sleeping, unusual dreams, and trouble concentrating. (These symptoms usually go away within 2 to 4 weeks of beginning treatment. However, they may become worse if you drink alcohol, take a medicine for mental health problems, or use certain street drugs.)
Seizures, which are more likely to happen if you have had seizures in the past.

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