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Modafinil, the active ingredient in wakefulness-promoting medications, acts on specific neurotransmitters in the brain to promote wakefulness and reduce sleepiness. It works by targeting the dopamine transporter, increasing dopamine levels in certain brain regions associated with wakefulness and motivation. Additionally, it affects other neurotransmitters such as norepinephrine and histamine, which play a role in promoting wakefulness and maintaining alertness.

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