Acetazolamide Tablets - Composition Therapeutic Uses Manufacturing Safety Guidelines

Acetazolamide Tablets are an essential pharmaceutical medication used in the treatment of glaucoma, epilepsy, altitude sickness, and various fluid-retention disorders. As a reliable carbonic anhydrase inhibitor, Acetazolamide helps regulate fluid balance, reduce intraocular pressure, and support effective diuretic action. Healthy Life Pharma Pvt. Ltd., a WHO–GMP certified and globally recognized manufacturer in India, produces high-quality Acetazolamide Tablets compliant with IP, BP, and USP standards to meet worldwide therapeutic needs.
Therapeutic Uses of Acetazolamide Tablets
Acetazolamide exhibits a diverse clinical profile, making it a trusted therapy across multiple medical specialties:
Ophthalmology: Effectively lowers intraocular pressure in chronic open-angle glaucoma and secondary glaucoma.
Neurology: Used as adjunct therapy in epilepsy due to its stabilizing action on abnormal neuronal firing.
Nephrology: Functions as a mild diuretic, aiding in the treatment of metabolic alkalosis and edema associated with heart failure.
Pulmonology & High-Altitude Care: Prevents acute mountain sickness by improving respiratory function and enhancing oxygenation at high altitudes.
Scientific Action & Pharmacology
Acetazolamide is a nonbacteriostatic sulfonamide derivative that reversibly inhibits carbonic anhydrase, an enzyme responsible for bicarbonate and sodium reabsorption.
Mechanism of Action:
By inhibiting carbonic anhydrase, Acetazolamide reduces hydrogen ion secretion, increases diuresis, and decreases aqueous humor formation—resulting in lower intraocular pressure.
Pharmacokinetics:
Absorption: Rapid oral absorption with 90–100% bioavailability
Protein Binding: ~90%
Metabolism: Minimal hepatic metabolism
Excretion: Eliminated unchanged via kidneys
Half-life: 10–15 hours

These properties support its effectiveness across ophthalmic, neurological, renal, and altitude-related conditions.