The brain loses cells when estrogen is low. This can be reversed. The brain can heal and regenerate, if given the right nutrition and hormones. An example is a woman who had Alzheimers at age 70 and is now driving at age 90. This is a documented case, by Dr. Nasr, where nutrition and hormones were used to regain health.Formula 41 Extreme Calcium without estrogen will not work to prevent osteoporosis. Sometimes only 10% of the calcium consumed is absorbed into the bones. Estrogen helps get the calcium into the bones. If no egg is released in the middle of a woman's menstrual cycle, no progesterone will be produced. This gives an overabundance of estrogen, which can cause problems. This is very common in women with PMS (Premenstrual Syndrome) involving bloating, night sweats, being easily irritated, and mood swings.