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Tirzepatide Tirzepatide is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide is also used to help lose weight and keep the weight off in patients with obesity caused by certain conditions. It is also used to treat moderate to severe obstructive sleep apnea (OSA) in patients with obesity.