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Depending on certain factors such as specific health conditions, type of strain and severity of the gut condition, it takes a specified amount of time for probiotics to work. Here is a general guide to understanding the timeline of probiotics effectiveness: Initial Digestive Benefits (Few Days To A Week) For some taking probiotics may elicit some results within the initial days to one week. This is particularly true for symptoms related to digestion: Reduced bloating, gas, and indigestion: Some may begin to feel better with these symptoms in 2 to 3 days after taking a probiotic. Regularity in bowel movements: For people suffering from irregular bowel movement, the use of probiotics may lead to the restoration of a regular bowel movement within the first week.