It depends on the infection and the likely bacteria. Impetigo is often treated with topical mupirocin, cellulitis usually with oral cephalexin, dicloxacillin, or clindamycin, and suspected MRSA with doxycycline or trimethoprim-sulfamethoxazole. A prescribed **skin infection antibiotic** such as amoxicillin-clavulanate may be chosen for bites and mixed infections. Skin is your largest barrier against bacteria, and a small break from a scratch, insect bite, shaving nick, or surgical wound can let germs in. Most infections respond well to timely treatment, yet the wrong drug, the wrong duration, or no medical assessment can let a minor problem become a hospital stay. This guide explains how clinicians choose antibiotics, what each option does well, where it falls short, and how to use it safely. It was prepared by the pharmacy content team at **A2Z RX LLC**, a licensed U.S. online pharmacy, and is educational rather than a substitute for an examination.