⚡ Fast-Acting Migraine Relief: Top Medicines For rapid migraine relief, triptans are the gold standard: Sumatriptan (Imitrex) or Eletriptan (Relpax) ease pain/nausea within 2 hours for 7 in 10 users. Use injections/nasal sprays for severe attacks. OTC options like Excedrin Migraine (aspirin + acetaminophen + caffeine) suit mild migraines but work for <50% of sufferers. Newer gepants (Ubrelvy, Nurtec) block migraine-triggering proteins without triptan side effects—ideal for high-risk patients.